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Hurlin
Lab
 Research
Interest:
I study the role
of the oncogene c-Myc, and its antagonist Mnt, in the immune
system. Mnt and c-Myc may play
roles in the maintenance of hematopoietic stem cell populations, the
development of lymphocytes (T and B cells), response to infections,
and cancer. I am currently studying how both of these proteins
affect development of T and B cells and how these proteins
contribute to tumor formation. Ultimately, my goal is to identify
any cancer-causing effects of these proteins that could be reversed.
BIOGRAPHICAL
SKETCH
Name:
Jason Link
Title:
Postdoctoral Fellow
Role on project: Postdoctoral Fellow
Institution & Location Degree Year(s) Field of
Study
Willamette University
B.S.
1997
Biology
University of Alabama at Birmingham Ph.D. 2002 Microbiology
Honors:
Immunology
Institutional Research Training Grant (T32) recipient (June
2001-December 2002)
Honorable Mention for 2001 Samuel B. Barker Award for Excellence in
Research by a Graduate Student, Department of Medicine, University
of Alabama at Birmingham
Research
and/or Professional Experience:
Postdoctoral Fellow,
Oregon Health & Science University Employee at Portland Shriners
Hospital, Mentored by Dr. Peter Hurlin, April 2008 - present
Research Enhancement
Award Program Fellowship Recipient,
Portland Veterans Affairs Medical Center,
February 2006 – February 2008
Microbiologist (under the mentorship of Arthur Vandenbark),
Portland VA Medical Center, January
2004 – February 2006
Postdoctoral Fellow, OHSU Department of
Neurology, February 2003 – January 2004
Peer-Reviewed
Publications (published, in press and submitted):
Link JM,
Rich CM, Korat M, Burrows GG, Offner H, Vandenbark AA. (2007)
Monomeric DR2/MOG-35-55 recombinant TCR ligand treats relapses of
experimental encephalomyelitis in DR2 transgenic mice. Clin
Immunol. 123(1):95-104.
Wang C, Chou YK, Rich CM, Link JM, Afentoulis ME, van Noort
JM, Wawrousek EF, Offner H, Vandenbark AA. (2006) AlphaB-crystallin-reactive
T cells from knockout mice are not encephalitogenic. J.
Neuroimmunol. 176(1-2):51-62.
Klyushnenkova EN, Link J, Oberle WT, Kodak J, Rich C,
Vandenbark AA, Alexander RB. (2005) Identification of
HLA-DRB1*1501-
restricted T-cell epitopes from prostate-specific
antigen. Clin Cancer Res. 11(8):2853-61.
Link JM, Larson JE, and Schroeder HW. (2005) Despite
extensive similarity in germline DH and JH sequence, the adult
Rhesus macaque CDR-H3 repertoire differs from human. Mol Immunol.
42(8):943-55.
Zemlin M, Ippolito GC, Zemlin C,
Link J, Monestier M, Schroeder HW Jr. (2005) Adult lupus-prone
MRL/MpJ2+ mice express a primary antibody repertoire that differs in
CDR-H3 length distribution and hydrophobicity from that expressed in
the C3H parental strain. Mol Immunol. 42(7):789-98.
Huan J, Meza-Romero R, Mooney J, Chou Y, Edwards D, Rich C, Link
J, Vandenbark AA, Bourdette DN, Bachinger HP, Burrows GG. (2005)
Rationally designed mutations convert complexes of human recombinant
T cell receptor ligands into monomers that retain biological
activity. Journal of Chemical Technology and Biotechnology.
80(1):2-12.
Finn TP, Jones RE, Rich C, Dahan R, Link J, David CS, Chou
YK, Offner H, Vandenbark AA. (2004) HLA-DRB1*1501 risk association
in multiple sclerosis may not be related to presentation of myelin
epitopes. J Neurosci Res. 78(1):100-14.
Chou YK, Culbertson N, Rich C, LaTocha D, Buenafe AC, Huan J,
Link J, Wands JM, Born WK, Offner H, Bourdette DN, Burrows GG,
Vandenbark AA. (2004) T-cell hybridoma specific for myelin
oligodendrocyte glycoprotein-35-55 peptide produced from
HLA-DRB1*1501-transgenic mice. J Neurosci Res. 77(5):670-80.
Rich C, Link JM, Zamora A, Jacobsen H, Meza-Romero R, Offner
H, Jones R, Burrows GG, Fugger L, Vandenbark AA.
(2004)
Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic
experimental autoimmune encephalomyelitis in HLA-DR2-transgenic
mice. Eur J Immunol. 34(5):1251-61.
Huan J, Subramanian S, Jones R, Rich C, Link J, Mooney J,
Bourdette DN, Vandenbark AA, Burrows GG, Offner H. (2004) Monomeric
recombinant TCR ligand reduces relapse rate and severity of
experimental autoimmune encephalomyelitis in SJL/J mice through
cytokine switch. J Immunol. 172(7):4556-66.
Zemlin,M, Klinger,M, Link J, Zemlin C, Bauer,K., Engler JA,
Schroeder,H.W.,Jr., Kirkham,P.M. (2003) Expressed murine and human
CDR-H3 intervals of equal length exhibit distinct repertoires that
differ in their amino acid composition and predicted range of
structures. J. Mol. Biol. 334(4):733-749.
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