oratorySelected Recent Publications
Original articles
Holden P, Keene DR, Lunstrum GP, Bächinger HP, Horton WA. Secretion of cartilage oligomeric matrix protein is affected by the signal peptide. J Biol Chem. 2005 Mar 3. PMID: 15749701
Humtsoe JO, Kim JK, Xu Y, Keene DR, Hook M, Lukomski S, Wary KK. A Streptococcal Collagen-like Protein Interacts with the α2β1 Integrin and Induces Intracellular Signaling. J Biol Chem. 2005 Apr 8; 280(14): 13848-57. Epub 2005 Jan 12. PMID: 15647274
Woodley DT, Keene DR, Atha T, Huang Y, Ram R, Kasahara N, Chen M. Intradermal injection of letiviral vectors corrects regenerated human dystrophic epidermolysis bullosa skin tissue in vivo. Mol Ther. 2004 Aug; 10(2): 318-26. PMID: 15294178.
Judge DP, Biery NJ, Keene DR, Geubtner J, Myers L, Huso DL, Sakai LY, Dietz HC. Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome. J Clin Invest. 2004 Jul; 114(2): 172-81. PMID: 15254584
Woodley DT, Keene DR, Atha T, Huang Y, Lipman K, Li W, Chen M. Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa. Nat Med. 2004 Jul; 10(7): 693-5. Epub 2004 Jun 13. PMID: 15195089
Charbonneau NL, Ono RN, Corson GM, Keene DR, Sakai LY. Fine tuning of growth factor signals depends of fibrillin microfibril networks. Birth Defects Res C Embryo Today. 2004 Mar; 72(1): 37-50. Review. PMID: 15054903.
Koch M, Schulze J, Hansen U, Ashwodt T, Keene DR, Brunken WJ, Burgeson RE, Bruckner P, Bruckner-Tuderman L. A novel maker of tissue junctions, collagen XXII. J Biol Chem. 2004 May 21; 279(21): 22514-21. Epud 2004 Mar 10. PMID: 15016833.
Corson GM, Charboneau NL, Keene DR, Sakai LY. Differential expression of fibrillin-3 adds to microfibril variety in human and avain, but not rodent, connective tissues. Genomics. 2004 Mar; 83(3): 461-72. PMID: 14962672
Woodley DT, Krueger GG, Jorgensen CM, Fairley JA, Atha T, Huang Y, Chan L, Keene DR, Chen M. Normal and gene-corrected dystrophic epidermolsys bullosa fibroblasts alone can produce type VII collagen at the basement membrane zone. J Invest Dermatol. 2003 Nov; 121(5): 1021-8. PMID: 14708601
Marneros AG, Keene DR, Hansen U, Fukai N, Moulton K, Goletz PL, Moiseyev G, Pawlyk BS, Halfter W, Dong S, Shibata M, Li T, Crouch RK, Bruckner P, Olsen BR. Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J. 2004 Jan 14; 23(1): 89-99. Epub 2003 Dec 11. PMID: 14685281
Ortiz-Urda S, Thyagarajan B, Keene DR, Lin Q, Calos MP, Khavari PA. PhiC31 integrase-mediated nonviral genetic correction of junctional epidermolysis bullosa. Hum Gene Ther. 2003 Jun 10; 14(9): 923-8. PMID: 12828862
Pappano WN, Steiglitz BM, Scott IC, Keene DR, Greenspan DS. Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases. Mol Cell Biol. 2003 Jul; 23(13): 4428-38. PMID: 12808086
Li J, Tzu J, Chen Y, Zhang YP, Nguyen NT, Gao J, Bradley M, Keene DR, Oro AE, Miner JH, Marinkovich MP. Laminin-10 is crucial for hair morphogenesis. EMBO J. 2003 May 15; 22(10): 2400-10. PMID: 12743034
Ortiz-Urda S, Lin Q, Green CL, Keene DR, Marinkovich MP, Khavari PA. Injection of genetically engineered fibroblasts corrects regenerated human epidermolysis bullosa skin tissue. J Clin Invest. 2003 Jan; 111(2): 251-5. PMID: 12531881
Veitch DP, Nokelainen P, McGowan KA, Nguyen TT, Nguyen NE, Stephenson R, Pappano WN, Keene DR, Spong SM, Greenspan DS, Findell PR, Marinkovich MP. Mammalian tolloid metalloproteinase, and not matrix metalloprotease 2 or membrane type 1 metalloprotease, processes laminin-5 in keratinocytes and skin. J Biol Chem. 2003 May 2; 278(18): 15661-8. Epud 2002 Dec 7. PMID: 12473650
Charbonneau NL, Dzamba BJ, Ono RN, Keene DR, Corson GM, Reinhardt DP, Sakai LY. Fibrillins can co-assemble in fibrils, but fibrillin fibril compositions displays cell-specific differences. J Biol Chem. 2003 Jan 24; 278(4): 2740-9. Epub 2002 Nov 11. PMID: 12429739
Isogai Z, Ono RN, Ushiro S, Keene DR, Chen Y, Mazzieri R, Charbonneau NL, Reinhardt DP, Rifkin DB, Sakai LY. Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein. J Biol Chem. 2003 Jan 24; 278(4): 2750-7. Epub 2002 Nov 11. PMID: 12429738
Chen M, Kasahara N, Keene DR, Chan L, Hoeffler WK, Finlay D, Barcova M, Cannon PM, Mazurek C, Woodley DT. Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa. Nat Genet. 2002 Dec; 32(4): 670-5. Epub 2002 Nov 11. PMID: 12426566
Steiglitz BM, Keene DR, Greenspan DS. PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1. J Biol Chem. 2002 Dec 20; 277(51): 49820-30. Epub 2002 Oct 20. PMID: 12393877
Ortiz-Urda S, Thyagarajan B, Keene DR, Lin Q, Fang M, Calos MP, Khavari PA. Stable nonviral genetic correction of inherited human skin disease. Nat Med. 2002 Oct; 8(10): 1166-70. Epub 2002 Sep 16. Erratum in: Nat Med. 2003 Feb; 9(2): 237. PMID: 12244305