Shriners Research Center, Portland OR

  Hurlin Lab
Research Interest:
Deregulation of Myc family proto-oncogenes has long been associated with human cancers. As a critical regulator of the cell cycle, Myc expression and protein function is tightly regulated at multiple levels. We have identified a novel method of Myc regulation by the MAPK signalling pathway that occurs at the translational level. My research focuses on elucidating the mechanism underlying the translation control of Myc mRNA and determining if this is process is deregulated during Myc-driven tumorigenesis. This work will further our understanding of normal and oncogenic functions of Myc family proteins and may provide new avenues for therapeutic advances in cancer treatment.