Shriners Research Center, Portland OR

CURRICULUM VITAE

Peter J. Hurlin
Associate Investigator, Research Center
Shriners Hospitals for Children -- Portland
Associate Professor of Cell and Developmental Biology
Oregon Health & Science University

INSTITUTION AND LOCATION DEGREE STUDY
Northern Michigan University, Marquette, MI, Zoology & Biochemistry, B.S., 1982
Michigan State University, East Lansing, MI, Biochemistry, Ph.D., 1988

HONORS
Individual National Research Service Award, 3/92-3/94
NIH Public Health Service Grant (RO1) 7/2000-7/2004
Shriners Hospitals for Children Research Award 1/2002 – 1-2008

RESEARCH AND/OR PROFESSIONAL EXPERIENCE
1999–Present Principal Investigator, Shriners Hospitals for Children, Portland, OR
1999–Present Assistant Professor, Department of Cell and Developmental Biology, Oregon Health & Science University, Portland, OR
1991–1999 Fred Hutchinson Cancer Research Center, Seattle, WA, Laboratory of Robert N Eisenman, Ph.D., Tumor Biology Section, Postdoctoral fellow.
1988–1991 Fred Hutchinson Cancer Research Center, Seattle, WA, Laboratory of James McDougall, Ph.D., Tumor Biology Section, Postdoctoral fellow.

PUBLICATIONS - Original Articles (1997-present)
1. Hurlin, P. J., Qúeva, C., Eisenman, R.N.: Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites. Genes & Development, 11:44-58, 1997.

2. Hurlin, P.J., Qúeva, C., Eisenman, R.N.: Mnt, a novel Max-interacting protein and Myc antagonist. Current Topics in Microbiology and Immunology: c-Myc in B-Cell Neoplasia, M. Poter and F. Melchers (Eds.). Springer. pp115-121, 1997.

3. Qúeva, C., Hurlin, P.J., Foley, K.P., Shiio, Y., Eisenman, R.N.: Sequential expression of the MAD family of transcriptional repressors during differentiation. Oncogene, 16:967-977, 1998.

4. Foley, K.P. McArthur, G.A, Quéva, C., Hurlin P.H., Soriano, P., Eisenman, R.N.: Targeted disruption of the MYC-antagonist Mad1 inhibits cell cycle exit during granulocyte differentiation. EMBO J, 17:774-785, 1998.

5. McArthur, G.A., Laherty, C.D., Queva, C., Hurlin, P.J., Loo, L., James, L., Grandori, C., Gallant, P., Shiio, Y., Hokanson, W.C., Bush, A.C., Cheng, P-F, Lawrence, Q.A., Pulverer, B., Koskinen, P.J., Foley, K.P., Ayer, D.E., Eisenman, R.N.: The Mad protein family links transcriptional repression to cell differentiation. Cold Spring Harbor Symposium on Quantitative Biology. Volume 63. Cold Spring Harbor Press, 1998.

6. Sommer, A., Waha, A., Tonn, J., Sorensen, N., Hurlin, P.J., Eisenman, R.N., Luscher, B., Pietsch, T.: Analysis of the Max-binding protein MNT in human medulloblastomas. Int J Cancer, 82(6):810-816, 1999.

7. Hurlin, P.J., Steingrímsson, E., Copeland, N. G., Jenkins, N. A., Eisenman. R. N.: Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif. EMBO J, 18(24):7019-28. 1999.

8. Zhou, Z-Q, Hurlin, P.J. The interplay between Mad and Myc in proliferation and differentiation. Trends in Cell Biology, 11(11):S10-4, 2001.

9. Carlson, H., Ota, S., Campbell, C.E., Hurlin, P.J. A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndrome. Human Molecular Genetics, 10(21):2403-13, 2001.

10. Carlson, H., Ota, S., Song, Y., Chen, Y., Hurlin, P.J. Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation. Oncogene, 21(24):3827-35, 2002.

11. Hurlin, P.J., Zi-Qiang Zhou, Z-Q, Toyo-oka, K., Ota, S., Walker, W.L, Hirotsune, S. and Anthony Wynshaw-Boris. Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J. 22(18):4584-4596. 2003.

12. Hurlin, PJ, Zhou, Zi-Qiang, Toyo-Oka, K, Ota, S, Walker WL, Hirotsune S, Wynshaw-Boris A. Evidence of Mnt-Myc antagonism revealed by Mnt gene deletion. Cell Cycle, 3(2):97-9. 2004.

13. Toyo-oka, K., Hirotsune S., Gambello, M.J., Zhou, Z-Q., Olson, L., Rosenfeld, M.G., Eisenman, R.N., Hurlin, P.J. and Anthony Wynshaw-Boris. Loss of the Max-interacting protein Mnt contained within the murine Miller-Dieker syndrome region results in defective embryonic growth and craniofacial defects. Human Molecular Genetics 13:1057-67. 2004.

14. Hurlin, P.J. and Dezfouli, F.S. Functions of Myc:Max in the control of cell proliferation and tumorigenesis. International Review of Cytology, Academic Press, K. Jeon, Editor. 238:183-226, 2004.

15. Walker, W.L., Fernandez, S. and Hurlin, P.J. Targeting Myc function in cancer therapy. Gene Therapy and Molecular Biology, 8:361-368, 2004.

16. Walker W, Zhou ZQ, Ota S, Wynshaw-Boris A, Hurlin PJ. Mnt-Max to Myc-Max complex switching regulates cell cycle entry. J. Cell Biol. 169:405-413. 2005.

17. Popov N, Wahlstrom T, Hurlin PJ, Henriksson M. Mnt transcriptional repressor is functionally regulated during cell cycle progression. Oncogene 24:8326-8337, 2005.

18. Hurlin PJ. N-myc functions in transcription and development. Birth Defects Res C Embryo Today. 75:340-352. 2005

19. Hooker CW, Hurlin PJ. Of myc and mnt. J. Cell Sci. 119:208-216. 2006

20. Dezfouli, F.S., Bakke, A, Wynshaw-Boris, A. and Hurlin, P.J. Disrupted T-cell homeostasis and lymphomagenesis caused by deletion of Mnt in T-cells. Mol. Cell. Biol. 26:2080-92. 2006

21. Hurlin P.J. and Huang J. The MAX-interacting transcription factor network Seminars in Cancer Biology, Semin Cancer Biol. 2006 Jul 14; [Epub ahead of print].

22. Toyo-oka K, Bowen TJ, Hirotsune S, Li Z, Jain S, Ota S, Escoubet-Lozach L, Garcia-Bassets I, Lozach J, Rosenfeld MG, Glass CK, Eisenman R, Ren B, Hurlin P, Wynshaw-Boris A. Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression. Cancer Res. 2006 Jun 1;66(11):5565-73.

23. Ota, S., Zhou, Z., Keene, D.R., Knoepfler, P., Hurlin, P.J. Activities of N-Myc in the developing limb link control of skeletal size and digit separation. Development. 2007 Apr;134(8):1583-92. Epub 2007 Mar 14.

24. Fernandez SL, Russell DW, Hurlin PJ, Development of human gene reporter cell lines using rAAV mediated homologous recombination, Biol Proced Online. 2007 Dec 24;9:84-90.  PMID: 18464937 [PubMed - in process]