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 Horton
Lab
BIOGRAPHICAL SKETCH
Name:
Catherine R. Degnin
Title: Postdoctoral
Research Associate
Institution & Location Degree
Year(s)
Field of Study
Seattle University B.S. 1982 Chemistry
Oregon Health and Sciences University
Ph.D. 2004 Biochem./Mol. Biol.
Major Research Interest: Trafficking of FGFR3 and mutant FGFR3 in
tissue culture cells and cultured chondrocytes
Research and/or Professional Experience:
2006-present Postdoctoral Fellow, Shriners Hospitals for Children,
Dr. William Horton
2004-2006
Postdoctoral Fellow, Molecular Medicine, Oregon Health and
Science University, Portland, Oregon. Dr. Joseph Weiss
1999-2004
Research Graduate Assistant, Department of Biochemistry
and Molecular Biology, Oregon Health and Science
University,
Portland, Oregon. Dr. Jan Christian
1993-1999
Research Associate, Vollum Institute of Advanced
Biomedical Research, Oregon Health and
Sciences University,
Portland, Oregon Dr. Mathew Thayer
1987-1993
Research Technologist,
Program in Molecular Medicine, Fred Hutchinson Cancer
Research
Center,
Seattle,
Washington
Dr. Adam Geballe
1984-1987
Research Technologist,
Department of Biochemistry University
of Washington,
Seattle,
Washington.
Dr. David
Morris
1982-1984
Research Technologist, Transplantation Biology
Fred
Hutchinson
Cancer
Research
Center, Seattle, Washington
Honors:
1978
Oregon
State
Scholar
1977-1979
Honors Scholarship, Seattle University
1979-1982
Academic Scholarship, Seattle University
1979-1982
Dean's List, College
of Science and Engineering, Seattle University
1979-1982
Alpha Sigma Nu, National Honor's Society
2000-2001
Oregon Cancer Center Training Grant
2001
Tartar Trust Fellowship
2002
PEO Scholar Award
Peer-Reviewed Publications (published, in press and submitted):
Johnson-Pais, T., Degnin, C.R., and Thayer, M.J. pRB induces Sp1
activity by relieving inhibition mediated by MDM2. Proc. Nat.
Acad. Sci. 98(5):2211-2216. 2001.
Howard, T.L., Stauffer, D.R., Degnin, C., and Hollenberg, S.M. CHMP1
functions as a member of a newly defined family of vesicle
trafficking proteins. J. Cell Sci. 114(13):2395-2404.
2001.
Guo, C.S., Degnin, C., Fiddler, T..A., Stauffer, D., Thayer, M.J.
Regulation of MyoD activity and muscle cell differentiation by MDM2,
pRB and Sp1. J. Biol Chem. 278(25):22615-22622. Epub Apr 17,
2003.
Book chapter: Hackermiller-Paradis, R., Degnin, C., Cellular
Processing and Signaling of BMP, Wnt and Hedgehog, Skeletal
Development and Disease: Molecular Principles and Interactions.
2003.
Degnin, C., Jean, F., Thomas G., and Christian, J.L.
Cleavages within the Prodomain direct intracellular trafficking and
degradation of mature BMP-4. Mol Biol Cell 15(11):5012-5020.
Epub Sep 8. 2004.
Sopory, S., Nelsen, SM., Degnin, C., Wong, C., Christian, JL.,
Regulation of bone morphogenetic protein-4 activity by sequence
elements within the prodomain. J Biol Chem.
281(45):34021-34031. Epub Sep 11. 2006.
Guo C, Degnin C.R., Laederich M.B., Lunstrum G.P., Holden P.,
Bihlmaier J., Krakow D., Cho J.Y., and Horton W.A. Sprouty 2
disturbs FGFR3 degradation in the achondroplasia group of human
skeletal dysplasias. Cell Signal. 2008 Apr 10. [Epub ahead of
pring] PMID: 18485666
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